Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Advanced Hematologic Cancer

• Status: Completed
• Trial end date: 2007-05-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells.

PURPOSE: Phase II trial to study the effectiveness of busulfan and melphalan followed by donor bone marrow transplantation in treating patients who have advanced hematologic cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Memorial Sloan Kettering Cancer Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Busulfan; Melphalan; Methotrexate; Tacrolimus

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of one of the following:

• Infant leukemia

• Acute lymphoblastic leukemia in 3rd or greater remission or relapse

• Undifferentiated or biphenotypic leukemia in 2nd or greater remission or relapse

• Juvenile chronic myelogenous leukemia (CML)

• Acute myelogenous leukemia (AML) in 3rd or greater remission or relapse

• Primary advanced myelodysplastic syndrome (MDS) excluding refractory anemia (RA) and RA with ringed sideroblasts

• Therapy-related MDS of any stage or AML

• CML in 2nd or greater chronic phase, accelerated, or blastic phase

• Acute leukemia, CML, or MDS but unable to tolerate total body irradiation (TBI) due to potential neurotoxicity (prior TBI, prior local radiotherapy,or under 2 years of age)

• No active CNS disease

• Related or unrelated bone marrow donor matched at HLA-A, B, and DR beta 1

PATIENT CHARACTERISTICS:

Age:

• Under 60 (over 60 considered on case-by-case basis)

Performance status:

• Karnofsky 70-100%

• Lansky 70-100%

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• AST and ALT less than 2 times upper limit of normal

• Bilirubin less than 1.5 mg/dL unless liver is involved with disease

Renal:

• Creatinine normal

• Creatinine clearance greater than 60 mL/min

Cardiovascular:

• Asymptomatic with no prior risk factors OR

• LVEF greater than 50% if symptomatic

Pulmonary:

• Asymptomatic with no prior risk factors OR

• Diffusion capacity greater than 50% predicted (corrected for hemoglobin) if symptomatic

Other:

• No active uncontrolled viral, bacterial, or fungal infection

• Not pregnant or nursing

• Negative pregnancy test

• HIV negative

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• More than 6 months since prior allogeneic or autologous stem cell transplantation

Chemotherapy:

• Not specified

Endocrine therapy:

• Not specified

Radiotherapy:

• See Disease Characteristics

Surgery:

• Not specified