Combination Chemotherapy Before Surgery in Treating Children With Localized Neuroblastoma

• Status: Completed
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed during surgery.

PURPOSE: Phase III trial to determine the effectiveness of combination chemotherapy given before surgery in treating children who have localized neuroblastoma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Societe Internationale d'Oncologie Pediatrique
• Collaborator: Children's Cancer and Leukaemia Group
• Treatments: Carboplatin; Cyclophosphamide; Doxorubicin; Etoposide; Liposomal doxorubicin; Vincristine

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of localized unresectable neuroblastoma

• Stage II or III

• No MYCN amplification

PATIENT CHARACTERISTICS:

Age:

• Over 1

Performance status:

• Not specified

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• Not specified

Renal:

• Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior chemotherapy

Endocrine therapy:

• Not specified

Radiotherapy:

• No prior radiotherapy

Surgery:

• Not specified