Overview
Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer
Status:
Completed
Completed
Trial end date:
2003-08-01
2003-08-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells. It is not yet known whether combination chemotherapy alone or combination chemotherapy plus radiation therapy is more effective for childhood kidney cancer. PURPOSE: Phase III trial to compare the effectiveness of combination chemotherapy with or without radiation therapy in treating children who have kidney cancer.Phase:
Phase 3Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Children's Oncology GroupCollaborator:
National Cancer Institute (NCI)Treatments:
Cyclophosphamide
Dactinomycin
Doxorubicin
Etoposide
Etoposide phosphate
Lenograstim
Liposomal doxorubicin
Vincristine
Criteria
DISEASE CHARACTERISTICS:- Histologically confirmed stage I-V kidney cancer of one of the following histologies:
- Wilms' tumor, favorable histology
- Wilms' tumor, focal or diffuse anaplastic
- Clear cell sarcoma
- Rhabdoid tumor
- (The rhabdoid tumor stratum closed to accrual effective 07/13/2001)
- Prior nephrectomy or biopsy required
- Prior bilateral biopsy (preferably open) with bilateral staging and pathologic
evaluation required for bilateral tumor
- Must begin study therapy within 5 days after nephrectomy (unless medically
contraindicated)
PATIENT CHARACTERISTICS:
Age:
- Under 16
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
Other:
- Not pregnant
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- No prior chemotherapy
Endocrine therapy:
- Not specified
Radiotherapy:
- No prior radiotherapy
Surgery:
- See Disease Characteristics