Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease
Status:
Withdrawn
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
Dupuytren's disease results in deformity of the hand and this can lead to trouble with daily
activities. Treatment traditionally involves cutting out diseased tissue, however this can
cause damage to important structures in the hand and results in large scars.
Needle aponeurotomy and collagenase injections are newer treatments that are thought to be
safer. These treatments allow quicker return to function. One drawback is that Dupuytren's
deformity may return more quickly than when all diseased tissue is surgically cut out.
This research study is designed to compare the effectiveness of needle aponeurotomy and
collagenase injection for Dupuytren's disease. This study will determine which procedure
gives the best results- either needle aponeurotomy, collagenase injection, or both procedures
in combination. Participants will be evaluated to see how they do in the long term.