Colchicine for Prevention of Vascular Inflammation in Non-cardio Embolic Stroke
Status:
Unknown status
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
This study evaluates the use of Colchicine in adults over 40 years of age who have suffered
an ischaemic stroke or transient ischaemic attack NOT caused by cardiac embolism or other
defined causes. Patients will be randomised to 0.5 mg/day of Colchicine plus usual care, or
to usual care alone.
To investigate the efficacy of low dose colchicine (0.5mg/day) plus usual care (defined as
antiplatelet, lipid-lowering, antihypertensive treatment, and appropriate lifestyle advice)
compared with usual care alone to prevent non-fatal recurrent ischaemic stroke, myocardial
infarction, cardiac arrest, hospitalization for unstable angina and vascular death after
ischaemic stroke or transient ischaemic attack (TIA) not caused by cardiac embolism or other
defined causes unrelated to atherosclerosis
Phase:
Phase 3
Details
Lead Sponsor:
University College Dublin
Collaborators:
Health Research Board, Ireland Irish Heart Foundation National University of Ireland, Galway, Ireland Universitaire Ziekenhuizen Leuven Universitat de Lleida University of Athens University of Edinburgh University of Limerick