Overview

Cognitive Therapy for Recurrent Depression

Status:
Completed
Trial end date:
2008-07-01
Target enrollment:
0
Participant gender:
All
Summary
This study determined the effectiveness of continuation phase cognitive therapy versus antidepressant medication in preventing relapse of depression in people with recurrent depression.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborator:
National Institute of Mental Health (NIMH)
Treatments:
Fluoxetine
Criteria
Inclusion Criteria:

- Recurrent unipolar major depressive disorder

- Have experienced at least two episodes of major depression

- Have experienced at least one period of recovery during a depressive episode or have a
history of dysthymia (a mood disorder characterized by depression) prior to the onset
of current or past depressive episodes

- Willing and able to comply with all study requirements

- Able to speak and read English

Exclusion Criteria:

- Active alcohol or other substance dependence within 6 months prior to study entry

- Currently at risk for suicide

- Mood disorders due to a medical condition or substance abuse

- Bipolar, schizoaffective, obsessive compulsive, or eating disorders

- Schizophrenia

- Unable to stop mood-altering medications

- Current use of medication or diagnosis of a medical disorder that may cause depression
(e.g., diabetes, head injury, stroke, cancer, multiple sclerosis)

- Previous failure to experience a reduction in depressive symptoms after 8 weeks of
cognitive therapy with a certified therapist

- Previous failure to experience a reduction in depressive symptoms after 6 weeks of 40
mg of Prozac

- Pregnancy or plan to become pregnant in the next 11-12 months

- Unable to attend clinic twice weekly during business hours

- Unable to complete questionnaires