Cognitive Functions After TIVA With Dexmedetomidine
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
It is important to wake up without any problem and comfortably from the general anesthesia.
The aim of this study is to investigate the effects of addition dexmedetomidine to the
balanced intravenous anesthesia with propofol over the cognitive functions and also it is
considered that the addition of dexmedetomidine would reduce the use of anesthetics drugs in
TİVA. Together with this effects, it has been considered that the disorder of the cognitive
functions in postoperative period and the need for anesthetic drugs in postoperative period
will be less.
After the approval of the Ethics Committee and the patients being informed and taking
informed consent from them 15 male 25 female totally 40 patients between the age of 20-60
years old, who had lumbar disc hernia, under general anesthesia have been taken under the
study. The patients have been divided into two groups by closed envelope drawing method,
randomly. All patients cognitive functions were evaluated by MMSE (Mini Mental State
Examination) during the premedication visit. For this study group Standardized Mini Mental
Test Examination (SMMT-E) were used, which has quite practical usage, for the untrained
patients, and test composed of question-answer in order to calculate the remembering, caution
and calculation structure and the scores were recorded. All patients had received the same
anesthesia induction with propofol infusion (started at firstly 12 mg. kg-1 for the 30
minutes, the second 30 minutes 9 mg. kg-1 and the BIS(bispectral index) values were arranged
between 40-60 until the end of the operation), and remifentanil infusion (0.5 μg.kg-1 was
applied as opioid and was arranged according to the tension artery and heart rate). In the
dexmedetomidine group, dexmedetomidine infusion had started as 0.5 μg.kg-1 without making the
loading dose and the dose change was not made. Rocuronium 0.5 mg. kg-1 iv. was applied for
the endotracheal intubation. After the operation all patients have taken to the recovery
room.
Then the tests of cognitive function evaluation were repeated as postoperative 2nd hour, 24
hours, 1 week and 1 month.