Cognitive Function and Pain Threshold in People Who Are Methadone Maintained
Status:
Completed
Trial end date:
2021-04-28
Target enrollment:
Participant gender:
Summary
Male and female participants, over the age of 18, with OUD currently receiving methadone will
be enrolled. This within-subject study design will assess pain and cognitive performance in
individuals with OUD engaged in MMT. Participants will be asked to complete two separate
4-hour sessions that will be spaced approximately 2-15 days apart. The two sessions will
differ based on methadone administration to evaluate study variables in methadone peak
(immediately after dose) and trough (20-24 hour after last dose) states. The order of these
sessions will be counterbalanced across participants. At the beginning of each session,
participants will complete a pain sensitivity task at baseline and post-methadone
administration to determine pain threshold and tolerance. Participants will then complete
computerized cognitive assessments of working memory, set-shifting, attentional bias, and
behavioral inhibition. The cognitive assessments will administered across three time-points
(0, 90, and 180 minutes). Pain threshold and tolerance will be measured again after 240
minutes. In addition, opioid craving, withdrawal, pain intensity, and emotional valence will
be repeatedly assessed during 240 minute session.