Cognitive Function and Addiction Under Opioid Tapering

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the effects of opioid dose reduction in the treatment of chronic pain in adults. Participants were divided in two groups: 1) patients that reduced opioid dose and 2) patients that kept the same opioid dose for six months.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Collaborators: Hørslev-Fonden; The Ministry of Science, Technology and Innovation, Denmark
• Treatments: Analgesics, Opioid; Fentanyl; Methadone; Morphine; Oxycodone; Tramadol

Criteria

Inclusion Criteria:

• age 18 years old or more

• at least seven years of schooling

• pain duration of at least six months,

• treatment with oral opioids for more than three months

• daily opioid dose ≥ 60 mg of oral morphine equivalent

Exclusion Criteria:

• not fluent in Danish language

• cancer disease

• poor general health condition

• pregnancy, dementia

• encephalopathy

• brain damage

• cranial base trauma

• enrolled in other studies