Cognitive Effects of Nimodipine in Patients With Schizophrenia
Status:
Suspended
Trial end date:
2023-01-01
Target enrollment:
Participant gender:
Summary
This study aims to evaluate the acute effects of nimodipine on cognitive performance in
patients with schizophrenia using a battery of cognitive assessments.The subjects will also
complete a 30-minute structural and functional MRI scan, with the goal of linking brain
activity with working memory performance. Investigators predict that the performance increase
induced by nimodipine will be greater in subjects who carry the A allele for the Calcium
Voltage-Gated Channel Subunit Alpha1 C (CACNA1C) risk single nucleotide polymorphism (SNP)
(rs1006737) in comparison to the response of G carriers.