Cognitive Effects of Inhalational Versus Intravenous General Anesthesia in the Elderly

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research is to determine if post-operative cognition will be better if the general anesthesia for surgery is done with an inhaled (gas through a breathing tube) or intravenous (medicine injected in the IV) general anesthetic technique.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Collaborators: US Department of Veterans Affairs; VA Office of Research and Development
• Treatments: Anesthetics; Isoflurane; Propofol

Criteria

Inclusion Criteria:

• patients (aged 65 years or older) scheduled for elective spine or major joint replacement (total hip or total knee arthroplasty) at Duke University Medical Center or the Durham VA Medical Center

Exclusion Criteria:

• not fluent in English and able to comprehend the English language

• have severe visual or auditory handicaps

• Carry a diagnosis of dementia or score < 18 on the Mini-Mental State Examination (MMSE) as calculated from the Modified Mini-Mental State (3MS) (see D4 below)

• have allergies to eggs, propofol, isoflurane, fentanyl, remifentanil, or pregabalin