Cognitive Correlates of Antidepressant Treatment Response in Elders
Status:
Completed
Trial end date:
2009-10-01
Target enrollment:
Participant gender:
Summary
Major depression is a very common health problem affecting older persons. The present
standard of treatment is with medications called "antidepressants". Antidepressants have been
studied extensively in older persons with normal brain function and have been shown to be
effective. However, certain types of brain dysfunction called "executive impairment"
(inability to do higher order thinking) may lead to poor treatment outcomes. This study will
compare how older depressed people with different levels of executive impairment respond
differently to standard antidepressant treatment. Knowing this information will lead to more
rational targeting of available treatments, leading to improved treatment outcomes.
Phase:
Phase 4
Details
Lead Sponsor:
St. Michael's Hospital, Toronto Unity Health Toronto