Overview

Cognitive Biases Under Ketamine

Status:
Unknown status
Trial end date:
2019-10-01
Target enrollment:
0
Participant gender:
All
Summary
Characterise cognitive biases resulting from low dose ketamine infusion, used as a pharmacological model of psychosis. Our assumption is that low dose ketamine results in reasoning biases by impairing the way uncertainty is monitored and taken into account for decision making.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Centre Hospitalier St Anne
Collaborators:
Association Schizo Oui
Comité pour la Recherche Hospitalière Médicale
Fondation Fyssen
Fondation pour la Recherche Médicale
Treatments:
Ketamine
Criteria
Inclusion Criteria:

- Right-handed (as assessed by the Edinburgh scale)

- Aged 18 to 39

- Having given an informed consent

- Health insurance

Exclusion Criteria:

- Pregnant or breastfeeding woman (a urine pregnancy test will be offered in doubt)

- Personal or first-degree family history of psychosis

- Personal history of mood disorder, anxiety disorder, obsessive-compulsive disorder,
somatoform disorder, dependence on a psychoactive substance, behavior disorder
incompatible with a 2 hours EEG recording.

- Psychotropic treatment, current or stopped for less than 1 month, including
antidepressant, anxiolytic but excluding hypnotic treatments.

- Personal history of neurologic disorder in relation to the central nervous system :
congenital malformation of the brain, brain tumor, multiple sclerosis, degenerative
disease of the central nervous system, epilepsy, current or in remission for less than
3 years or still requiring a medical treatment, inflammatory disease of the central
nervous system dating under a year or having resulted in sequelae.

- Known hypertension or blood pressure above 140/90 mmHg upon clinical examination,
congenital heart disease, ischemic heart disease, cardiac insufficiency,
supraventricular and ventricular heart rhythm disorder.

- Person with restricted liberty, as a result of judicial or administrative measures

- Persons under involuntary commitment as a result of a psychiatric disorder.

- Person subject to a measure of legal protection or unable to consent.

- Known intolerance ketamine.