Cluster Randomized Trial of Initial Oxygen Concentration at Birth in Late-Preterm Infants
Status:
NOT_YET_RECRUITING
Trial end date:
2029-12-31
Target enrollment:
Participant gender:
Summary
This study is trying to figure out the best amount of oxygen to give preterm babies (born between 32 and 35 weeks) right after birth. In the past, doctors used high levels of oxygen, but research has shown that using lower levels might help reduce the risk of death in full-term babies without harming brain development. However, we don't know the best oxygen level for babies born a little early (32 to 35 weeks). Some early data suggests that giving lower oxygen levels (FiO2 0.3) may not help babies reach healthy oxygen levels by 5 minutes after birth. This study will compare three oxygen levels-FiO2 0.6, FiO2 0.3, and air (FiO2 0.21)-to see which helps babies breathe better and need less ongoing breathing support. Researchers will study over 1,100 babies in hospitals across Alberta, Canada, to find the safest approach for these babies.