Clove In The Treatment Of Relapsed Or Resistant Acute Leukemia In Children
Status:
Completed
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
Study Hypothesis. combination chemotherapy with Clofarabine VP16 and Cyclophosphamide is able
to induce remission in resistant/refractory acute leukemias in pediatric.
Forty children with relapsed or refractory Acute Lymphoblastic Leukemia (ALL) or Acute
Myeloid Leukemia (AML) entered the study and received the association of clofarabine (40
mg/m2/day) in combination with etoposide (100 mg/m2/day) and Cyclophosphamide (440 mg/m2/day)
in 1 or 2 induction cycles End point were complete remission (CR)or CR without platelet
recovery (CRp) and toxicity