Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants
Status:
Completed
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
Pharmacological closure of ductus arteriosus with prostaglandin (PG) inhibitors has been used
for years. Previous studies indicated that ibuprofen has similar effect on ductal closure as
indomethacin but has less adverse effects on renal function, cerebral blood flow and
mesenteric blood flow.1-7 There are, however, very few studies being done specifically on
extremely low birth weight (ELBW) infant < 1000 g. This group of infants has immature kidney
and often has poor response to PG inhibitors and has high mortality and morbidity. We
hypothesized that, in ELBW infants, the ductal and renal response to PG inhibitors may be
different between indomethacin and ibuprofen.
Phase:
N/A
Details
Lead Sponsor:
Taipei Medical University Hospital
Collaborators:
China Medical University Hospital John H. Stroger Hospital