Closing Volume Interpretation and Bronchodilators Effect
Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
- The gold standard measures to evaluate small airways (SAW) "in vivo" is not well
understood
- Two tests are today used to measure SAW but real results concordance is not clear
- These problems have a small evidence
- Data about real effect of bronchodilators on SAW (eg Tiotropium and Indacaterol) has
never been studied
- Only an acute bronchodilators effect, after one hour of drugs inhalation, will be
evaluated
- The time frame of study evaluations per patient will be of three hours: one hour for
basal test; one hour rest after drug administration; one hour for post bronchodilators
test
- All enrolled subjects will be outpatients and will be evaluated after 24 hours of
inhalatory drugs washout