Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Prospective within-subject study of dexmedetomidine sedation paired with CLAS conditions in repeated blocks. Intervention will consist of CLAS in-phase with EEG slow waves. Anti-phase stimulation will serve as an active control while sham stimulation will serve as a passive control.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Washington University School of Medicine
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• Age 18-40 years

• Healthy volunteers (American Society of Anesthesiologists Physical Status 1-2).

Exclusion Criteria:

• Diagnosed sleep disorders

• Habitually short sleepers

• Diagnosed psychiatric disorders

• Use of psychoactive medication (e.g., antidepressants, mood stabilizers or antipsychotics), diagnosed hearing disorder

• Neck circumference > 40 cm

• Body Mass Index > 30

• Acknowledged recreational drug or nicotine use

• Resting heart rate during slow wave sleep < 40 beats per minute

• Pregnancy or nursing

• Persistently inconsistent or elevated QST heat pain tolerance thresholds (>50 ºC).