Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos.
Status:
Completed
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting
approximately 6-10% of women of reproductive age. Anovulation, infertility and
hyperandrogenism often co-exist with hyperinsulinaemia and insulin resistance .
Clomiphene citrate remains the standard drug for induction or augmentation of ovulation.
However, it is not equally effective in all situations, and therefore it may require
additional expensive drugs such as N-acetyl cysteine, as an antioxidant, has been suggested
as an adjuvant in clomiphene-resistant cases .NAC may also improve the circulating level of
insulin and insulin sensitivity in hyperinsulinaemic women with PCOS, and may be useful for
the treatment of insulin resistance by ameliorating the homocysteine and lipid profile in
PCOS .