Clinical and Angiographic Outcomes With Hyperglycemic Control Post PCI
Status:
Completed
Trial end date:
2005-09-01
Target enrollment:
Participant gender:
Summary
Coronary artery disease is a process that results in "hardening of the arteries". When the
arteries that supply blood and oxygen to your heart muscle become clogged or narrowed, a
heart attack may result, or you may feel chest discomfort (angina) - sometimes even while
resting. One approach to treating this condition is a balloon procedure known as coronary
angioplasty.
The major limitation of coronary angioplasty is renarrowing of the artery (restenosis) in the
first six months following the procedure requiring either repeat angioplasty or referral for
bypass surgery. Patients with diabetes have always been identified as having higher rates of
restenosis and poor outcomes following angioplasty, despite some important scientific
advances. We think that the level of blood sugar control at the time of angioplasty and in
the following months may be related to the extent of restenosis.
We expect that a reduction in blood sugar with insulin may, in turn, reduce the restenosis
process and improve your long-term outcome.