Clinical Trials to Reduce the Risk of Antimicrobial Resistance
Status:
Terminated
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to demonstrate a low rate of emergence of antibiotic
resistance in P. aeruginosa and Acinetobacter spp during the treatment of hospitalized
patients with pneumonia requiring mechanical ventilation treated with PD optimized meropenem
administered as a prolonged infusion in combination with a parenteral aminoglycoside plus
tobramycin by inhalation (Group 1) compared to therapy with meropenem alone (Group 2 -
control arm).