Clinical Trials of Continuous Oxygen Therapy Combined With Blue Light Deprivation in the Treatment of Retinitis Pigmentosa

• Status: Not yet recruiting
• Trial end date: 2025-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the role of continuous oxygen therapy combined with blue light deprivation in prevention and control of retinitis pigmentosa, in order to find a new strategy of treatment for retinitis pigmentosa.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sun Yat-sen University
• Collaborators: Guangzhou Jeeyor Medical Research Co.,Ltd.; Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; Zhujiang Hospital
• Treatments: Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

1. Severe patients with RP who meet the following criteria: (1) the EDTRS visual acuity of the good eye < 0.3 (low vision);(2) the radius of central visual field< 10 °(low vision)

2. Age range from 18 to 60 years old, sex unlimited

3. Able to adhere to treatment for more than 12 months

4. Willing to participate in this trial, and sign the informed consent

Exclusion Criteria:

1. Serious opacity of cornea, lens or vitreous body which can't have clear fundus examination

2. Patients with severe systemic diseases who was unable to tolerate the examinations, such as heart failure, respiratory failure, sepsis, severe anemia, kidney disease, history of eye surgery and so on

3. Patients who was unable to tolerate oxygen treatment, such as severe pulmonary edema, deformity of the respiratory tract, respiratory tract infection, tuberculosis, patients with pregnancy, and so on