Clinical Trial on Individual Characteristics Affecting Pain Drug Therapy in Neonates
Status:
Completed
Trial end date:
2019-01-31
Target enrollment:
Participant gender:
Summary
Children differ from adults with respect to growth and development but also immaturity of
various pharmacological mechanisms. Dosing schemes in children are usually derived in an
empirical manner from clinical trials in adult patient groups. All this poses neonates to an
increased risk for therapeutic failure and adverse drug reactions.
Medicinal products studied during this project are among the ones with the highest needs for
research in the pediatric intensive care. This project focuses on the necessity to integrate
subject's individual characteristics to assist clinical decision-making in drug therapy. The
investigators explore the mechanisms defining the dose response in pediatric populations. The
results obtained with these studies will help to find safer drug dosing regimens in this
delicate patient population.
Phase:
Phase 4
Details
Lead Sponsor:
Turku University Hospital
Collaborators:
Helsinki University University of Helsinki University of Turku