Overview

Clinical Trial of YY1201 for Treatment of Osteoarthritis of the Knee

Status:
Withdrawn
Trial end date:
2016-10-01
Target enrollment:
0
Participant gender:
All
Summary
This is a multicenter, randomized, double-blinded, parallel, placebo-controlled, phase I/IIa clinical trial of YY1201 for treatment of osteoarthritis of the knee.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Yooyoung Pharmaceutical Co., Ltd.
Yooyoung Pharmaceutical Co.,Ltd.
Criteria
Inclusion Criteria:

1. Males or Females 40 years and older

2. According to the clinical diagnosis standard of the American College of Rheumatology
(ACR), someone, diagnosed as a single/both sides of osteoarthritis, who corresponds to
over 3 conditions of followings.

- Over 50 years of age

- Less than 30 minutes of morning stiffness

- Crepitus on active motion

- 4 bony tenderness

- Bony enlargement

- Nopalpable warmth of synvium

3. Within 6 months from screening visit, someone who diagnosed with Kellgren & Lawrence
Grade I~III by the radioactive examination.

4. By the Weight-bearing pain(100mm-VAS) examination, someone who has a outcome of the
single or both sides of the osteoarthritis is over 40mm

5. Patient (No-responder) who has experienced steady pain in spite of dosing NSAIDs or
other pain-killers in the past.

6. Patient who can walk by themselves without helper like cane or walker etc. (If the
patient who has used helper routinely from previous 6 months, evaluating the patient
including the helper is possible. In this case, patient needs to use same helper
continuously by end of the clinical trial test.)

7. Patient who agrees to participate in this clinical trial by themselves.

Exclusion Criteria:

1. Someone who has BMI≥32kg/m² at the screening visit.

2. Patient who has an experience dosing psychoactive drug, narcotic analgesic which can
have an effect on pain sense over 3 months habitually.

3. Patient who has been administrated gastrointestinal drug(for example H₂-blockers,
misoprostol or proton pump inhibitors) regularly, who can't stop injecting for
clinical study period.

4. Patient has attended abnormal values from screening test(2 times excess at upper limit
of the normal values at ALT, AST, BUN, Serum Creatinine).

5. Patient who has rheumarthritis or other inflammatory metabolic arthritis.

6. Patients having serious gastrointestinal, liver, renal, heart disease.

7. When the inflammatory disease is occurred on joint area to patient like septic
arthritis.

8. Patients having skin ailment at the injecting site of the joint region.

9. Patients having secondary osteoarthritis according to the Ochronosis, Hemochromatosis
or systemic disease.

10. Patients who have severe pain like Sudek's atrophy, Paget's disease, Spinal disc
herniation.

11. Poly-articular patients who have suffered seriously by osteoarthritis at other parts
affect judge of the knee joint pain.

12. Patients who diagnosed clear interval disappearance at the knee joint by X-ray.

13. Patients who were administrated below drugs before baseline visit.

- Patients who were injected HA at the target knee joint in recent 9 months.

- Patients who were injected HA at other parts of the knee joint in recent 6
months.

- Patients who were injected steroids into the intra-articular knee joint.

- Patients who were administrated steroids systemically by the oral medication
(But, except inhalation)

14. Patients who have joint effusion trouble were judged as a positive by tests like
Patella tap test.

15. Patients who have target knee joint gotten surgical operation history including
Arthroscopy within past one year (In case of having other side of knee joint or hip
joint gotten surgical operation history, excepting the patients if there is
possibility which can influence the target knee joint's appraisal.

16. Patients who have an operation history about target knee joint.

17. Patients who do the height weight aerobic exercise or anaerobic exercise.

18. Patients who need to be administrated anticoagulant agent together(But, except 300mg
daily dose aspirin)

19. Patients who have hypersensitivity history about Investigational Product.

20. In the midst of women in their childbearing years, patients who disagree to do *
contraception by medically permitted method for 12 weeks from administrating
investigational product.

* The contraception by medically permitted method: Condom, In case of using injection
or insertion, In case of installing a intrauterine contraception device etc.

21. Patients who were injected other investigational product over a time within 30 days
before participated in this clinical trail.

22. Besides that, the patients who have difficulty to be participated in this clinical
trial continuously by Principle Investigator (PI)'s decision.