Clinical Trial of Lamotrigine to Reverse Cognitive Impairment in Chronic Corticosteroid-Treated Patients
Status:
Completed
Trial end date:
2005-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if lamotrigine therapy is associated with
improvement in mood, memory and hippocampal size and function in patients receiving chronic
corticosteroid therapy. Standard care for mood changes associated with corticosteroid
therapy, if severe, includes antidepressants or other medications which can influence mood.
No therapies, other than dose reduction or discontinuation, are currently available for
memory loss associated with corticosteroid treatment. However, very little information is
available on the treatment of either mood or memory changes associated with corticosteroid
treatment, thus the proposed project may improve standard care.