Overview

Clinical Trial of Donepezil Between the Patients With Alzheimer's Disease and Mixed Dementia

Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
0
Participant gender:
All
Summary
To compare the clinical efficacy of donepezil between patients with Alzheimer's disease and Mixed Dementia.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Samsung Medical Center
Collaborator:
Eisai Korea Inc.
Treatments:
Donepezil
Criteria
Inclusion Criteria:

1. A diagnosis of probable AD and Mixed Dementia according to the criteria of the
NINCDS-ADRDA

2. Korean version Mini-Mental State Examination scores between 10 and 26

3. History of cognitive decline that had been gradual in onset and progressive over at
least 6 months

4. A caregiver who could assist the patient with medication, attend the assessment and
provide information about the patient.

Exclusion Criteria:

1. they had evidence of any neurodegenerative diseases other than AD (i.e. Parkinson's
disease, Huntington's disease)

2. Psychiatric disorder or severe behavioral disturbances that required psychotropic
medications

3. Cerebral injuries induced by trauma, hypoxia, and/or ischemia

4. Clinically active cerebrovascular disease; History of seizure disorder

5. Other physical conditions that required acute treatment.