Clinical Trial of Desmopressin on Nocturia in Obstructive Sleep Apnoea Patients

• Status: Terminated
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to evaluate the efficacy of desmopressin on symptoms of nocturia in patients with Obstructive Sleep Apnoea (OSA). The improvement of sleep quality and the quality of life will be measured.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese University of Hong Kong
• Treatments: Deamino Arginine Vasopressin

Criteria

Inclusion Criteria:

• Adult male or female patient (aged
• Obstructive sleep apnoea diagnosed by sleep study

• Stable treatment on obstructive sleep apnoea and / or LUTS

• Nocturia on average more than once per night

• Having the ability to communicate and comply with the requirements of the study

Exclusion Criteria:

• Presence of urethral strictures and neurogenic bladder dysfunction

• Clinical evidence of bladder stones, bladder tumor or an active urinary tract infection

• History of prostate cancer or prostate specific antigen (PSA) level > 10ng/ml or suspicious of prostate cancer on digital rectal examination (DRE), unless a transrectal biopsy of prostate has been performed and the presence of prostate cancer has been excluded.

• Patient on intermittent self-catheterisation

• Recent start or change of treatment on obstructive sleep apnoea and / or nocturia

• Uncontrolled medical problems: e.g. Diabetes Mellitus or Diabetes insipidus

• Hyponatraemia

• Pregnancy