Clinical Trial of Antioxidant Therapy in Patients With Septic Shock
Status:
Active, not recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
Sepsis and septic shock are public health problems worldwide that represents an excessive
cost for health systems. Despite the great technological and research advances, mortality can
reach up to 80% in patients with multiple organ failure (FOM). Therapeutic studies focused on
evaluating the usefulness of the use of antioxidants have shown different outcomes and
results. This randomized clinical trial in patients with septic shock at two general
intensive care units try to evaluate the usefulness of four different antioxidant therapies
added to the conventional treatment, which includes: n-acetyl cysteine, vitamin C, vitamin E
and melatonin. Measurement of parameters before and after treatment of oxidative stress
includes nitrates and nitrites, lipid peroxidation, glutathione peroxidase, glutathione s
transferase, extracellular activity of SOD, GSH concentration and evaluation of total
antioxidant capacity. The investigators will also evaluate the clinical impact of antioxidant
therapy with the SOFA score.