Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation
Status:
Completed
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
Axillary hyperpigmentation is a frequent consultation in dark skin populations although its
exact prevalency is unknown. Currently, there are not studies about physiopathology and
treatment for this entity. The objective is to evaluate the depigmenting effect of topical 4%
niacinamide versus 0.05% desonide in axillary hyperpigmentation.
At least 30 axillas with hyperpigmentation in individuals of phototype III-V, aged 18-50
years are going to be randomly assigned to receive niacinamide, desonide or placebo daily. No
hygienic habits will not be modified. Volunteers will be evaluated at baseline and for 9
weeks, by means of histological, histochemical and immunohistochemistry analysis, as well as
Transepidermal Water Loss (TEWL), colorimetry, clinically and by photography control.