Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

• Status: RECRUITING
• Trial end date: 2027-01-01

Summary

The aim of this trial is to test whether postoperative antibiotics targeted towards bacteria in the urine can reduce the risk of infection after surgical removal of the bladder (cystectomy) compared to a standardised antibiotic prophylaxis.

Participants undergoing cystectomy will be randomly assigned to postoperatively receive (A) a standardised orally administered antibiotic prophylaxis currently given at Rigshospitalet, Copenhagen or (B) a conventional orally administered antibiotic prophylaxis targeting bacteria found in the urine postoperatively.

The investigators' hypothesis is that the targeted prophylactic antibiotic strategy will reduce the number of infection-related readmissions within 90 days of surgery compared to the standardised prophylaxis.

• Phase: PHASE4

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Treatments: Amdinocillin Pivoxil; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Cefuroxime; Ciprofloxacin; Fluconazole; Linezolid; Nitrofurantoin; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination