Clinical Study of UMOD NKCC2 Interaction on Salt-sensitivity in Hypertension
Status:
Recruiting
Trial end date:
2021-08-25
Target enrollment:
Participant gender:
Summary
The hypothesis is based on UMOD rs13333226 genotype, there are two strata of hypertensive
patients. The High-UMOD group (AA genotype) has increased UMOD excretion, greater salt
sensitivity, HTN, normal eGFR and greater BP response to loop diuretics like furosemide. The
Low-UMOD group (G allele) has decreased UMOD excretion, salt resistance, increased eGFR,
increased proximal tubular reabsorption of Na (possibly related to increased GFR), a poor BP
response to loop diuretics, and possibly diminished function of NKCC2. The High-UMOD strata
will have decreased delivery of Na+ to the distal tubule and collecting duct because NKCC2
function is normal and the study hypothesis is that the participants will be more responsive
to loop diuretics. In contrast, the Low-UMOD group (G allele) will not show a similar
response to loop diuretics. This may be related either to lower Na delivery to the TAL,
because of increased proximal tubular reabsorption of Na+, or a suppressed function of NKCC2.
The population distribution of the High-UMOD group (AA) is 67%. Our overall objective is to
test the hypothesis that hypertensive subjects with uncontrolled HTN open possessing the AA
genotype of rs13333226 will be better responders to loop diuretics compared to those
possessing the G allele.