Clinical Study Evaluating the Safety of Lactobacillus Probiotic in Children With Drug Resistant Epilepsy
Status:
Not yet recruiting
Trial end date:
2024-01-01
Target enrollment:
Participant gender:
Summary
Animal and human studies have brought up evidence supporting Gut microbial disbalance, namely
dysbiosis, as a causative factor of epilepsy, especially the refractory form. thus,
probiotics might constitute a safe, low-cost, and effective supplementary therapy in patients
with DRE.
The Lactobacillus population is probiotic bacteria that have a beneficial role in epilepsy.
Lactobacillus can influence brain function through the modulation of GABA, as shown in rodent
models. Moreover, it has been demonstrated in animal models of epilepsy and in human
epileptic patients that probiotic treatment aimed at restoring gut microbiota equilibrium has
beneficial effects on epileptic symptoms by increasing GABA in animals and the levels of
Bifidobacteria and Lactobacillus in humans.