Clinical Phase III Trial Treosulfan-based Conditioning Versus Reduced-intensity Conditioning (RIC)
Status:
Completed
Trial end date:
2018-01-25
Target enrollment:
Participant gender:
Summary
This randomized allogeneic transplantation protocol compares i.v. Treosulfan-based
conditioning therapy with reduced intensity i.v. Busulfan-based conditioning in adult AML and
MDS patients at increased risk for standard conditioning therapies. The protocol is based on
results of previous phase I/II trials evaluating Treosulfan/Fludarabine conditioning prior to
allogeneic haematopoietic stem cell transplantation. The reference arm (reduced intensity
i.v. Busulfan/Fludarabine) is considered to be accepted medical practice for the study
patient population.