Clinical Pharmacogenetic of Ibuprofen After Lower Third Molar Surgeries
Status:
Unknown status
Trial end date:
2020-07-01
Target enrollment:
Participant gender:
Summary
The present clinical trial randomized will be to assess the link between the different
haplotypes of CYP2C8 and CYP2C9 genes and the clinical efficacy of ibuprofen after lower
third molar extractions. Onset, duration of postoperative analgesia, duration of anesthetic
action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth
opening and wound healing at the 7th postoperative day were evaluated. For this purpose, 200
healthy volunteers underwent removal of one lower third molar, under local anesthesia with
articaine 4% (1:200,000 adrenaline) will be genotyped and phenotyped for these genes and
their postoperative records with all data collected will be compared with the haplotypes
found in the Brazilian population.
Phase:
Phase 4
Details
Lead Sponsor:
University of Sao Paulo
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo