Clinical Outcomes of Cyclosporine Eye Drops in Management of Herpetic Keratitis
Status:
Recruiting
Trial end date:
2023-03-01
Target enrollment:
Participant gender:
Summary
Objective: To compare the additive effect of topical cyclosporine A 0.05% eye drops to
prednisolone eye drops, with topical prednisolone acetate 1% eye drops alone in treatment of
herpetic stromal keratitis.
Methods: Patients diagnosed with herpetic stromal keratitis are randomly divided into 2
groups; Group A: receive cyclosporine eye drops together with prednisolone eye drops.
Group B: receive topical prednisolone with placebo eye drops (tear replacement).
The 2 groups receive systemic acyclovir therapeutic dose 400 mg five times daily, which then
tapered to twice daily prophylactic dose after one month of treatment. Follow up for patients
is scheduled as a weekly visit for a duration of 2 months.