Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine
Status:
Completed
Trial end date:
2017-09-01
Target enrollment:
Participant gender:
Summary
Anecdotal reports suggest buffering lidocaine with epinephrine just before intraoral
injection reduces time of onset, results in a deeper anesthetic effect, without the "sting"
with injection from a low pH. Additional data are needed to establish clinical important
outcomes such as the peak blood level of lidocaine as compared to the non-buffered drug
combination.
Clinical pilot studies are proposed as the start of a series of investigations to support or
modify the use of the buffered anesthetic for intraoral procedures.