Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a
larger NIH-funded study to evaluate the analgesic efficacy of three doses of chronic oral
(PO) dextromethorphan compared to placebo in central neuropathic pain following spinal cord
injury. Subjects' maximally tolerated doses (MTD) were first determined to establish
individual dose-analgesic response relationships in a run-in period; following a washout
period, subjects were then randomized to receive an order of four doses of dextromethorphan
(including placebo) in a 4x4 Latin square cross-over design.
Phase:
Phase 2
Details
Lead Sponsor:
Brigham and Women's Hospital
Collaborator:
National Institute of Neurological Disorders and Stroke (NINDS)