Clinical Impact of Del Nido Cardioplegia in Adult Cardiac Surgery
Status:
Unknown status
Trial end date:
2020-02-28
Target enrollment:
Participant gender:
Summary
Cardioplegia solutions have been used for myocardial protection in cardiac surgery for
decades. Different cardioplegic strategies have been evaluated.
Del Nido cardioplegia was initially used in pediatric patients and has been expanding into
adult cardiac centers over the last decade. It can be used as a single dose and it is a
reasonable tool do decrease cardioplegic interventions. Recent meta-analysis based on 9
retrospective studies has shown that "clinical outcomes of Del Nido cardioplegia are
noninferior to the outcomes of conventional cardioplegia in adult cardiac surgery".
To assess the potencial benefits of Del Nido cardioplegia we performed this clinical trial to
evaluate superiority of Del Nido cardioplegia compared to cold blood cardioplegia in terms of
myocardial protection and clinical-related outcomes. 474 participants will be randomized
either into Del Nido cardioplegia protocol or into the cold blood cardioplegia protocol.
Perioperative outcomes will be presented.