Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR
Status:
Unknown status
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Rural communities involved in agriculture are often at highest risk of insect-borne diseases
in Southeast (SE) Asia.
Skin-applied insect repellents may prove a useful means of reducing mosquito-borne diseases
for those people working outdoors in high risk areas.
This trial is evaluating the use of insect repellent (20% diethyltoluamide) to reduce
incidence of malaria, Japanese Encephalitis and Dengue. The investigators will recruit up to
1000 households from 100 villages in rural Laos. In each house the investigators shall
recruit up to 5 individuals. Half of households will be randomised to repellent, half to a
placebo. All individuals will be provided with insecticide treated bed nets for use at night.
All household occupants will be followed for 7 months to record malaria cases by Rapid
Diagnostic Test every month. Blood spots will be collected at start and end of study to
measure Japanese Encephalitis and Dengue. All positive cases will be promptly treated.
Outcome will be reduction in number of malaria cases (primary outcome) and Dengue/Japanese
Encephalitis (secondary outcomes).