Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
To examine the clinical efficacy of sertraline (200 mg/day) alone or sertraline in
combination with gabapentin. The purpose of this study is to examine whether the
antidepressant sertraline alone or combined with gabapentin delays time to relapse relative
to placebo in recently abstinent cocaine-dependent volunteers who are also depressed. In
addition, whether depressive symptoms or genetic factors influence treatment response to the
study medications will be examined. Our hypothesis is that those on combined
sertraline-gabapentin will show a longer period of abstinence than those on sertraline alone
or placebo.