Clinical Efficacy of Lisdexamfetamine for Methamphetamine Dependence
Status:
Completed
Trial end date:
2016-05-19
Target enrollment:
Participant gender:
Summary
Methamphetamine dependence is a serious public health problem, with methamphetamine abusers
being at risk for significant morbidity and mortality, including HIV. To date, no medication
or psychotherapeutic strategy has shown robust, long-term efficacy in treating this disorder.
This clinical trial will examine whether lisdexamfetamine shows promise in alleviating
withdrawal symptoms and preventing relapse relative to placebo in recently-abstinent
methamphetamine dependent individuals. Findings of this study will not only shed light on
whether lisdexamfetamine may improve upon treatment for this disorder but also inform future
medication development strategies for improving treatment for drug dependence disorders.
Discovering efficacious limited risk interventions that show more robust, longer-term
outcomes would be beneficial both to the individual and society.