Clinical Efficacy of Indomethacin in Early Treatment of Acute Pancreatitis
Status:
Not yet recruiting
Trial end date:
2023-12-11
Target enrollment:
Participant gender:
Summary
Acute pancreatitis is a common critical disease of the digestive system. Accumulated data
showed that overexpression of cyclooxygenase-2 (COX-2) in acute pancreatitis and experimental
pancreatitis could be attenuated with COX-2 inhibitors. In recent years, it has been found
that timely administration of indomethacin or diclofenac sodium to anus after ERCP can
significantly reduce the incidence of AP after ERCP in patients at high risk of AP. The aim
of this study was to evaluate the efficacy of rectal indomethacin in reducing the systemic
inflammatory response syndrome (SIRS) score in AP patients.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University