Overview

Clinical Effects and Cost-effectiveness Analysis of Early Anti-viral Therapy on HBV-related Compensated Liver Cirrhosis

Status:
Unknown status
Trial end date:
2018-12-01
Target enrollment:
0
Participant gender:
All
Summary
Though newly reported HBV infection and HBsAg prevalence in China have greatly decreased, patients who had been chronically infected with HBV, especially those with liver cirrhosis cause great burden on public health care. In view of economic development level, drug availability and lack of independent health economics evidence, the investigators are still unable to give specific guidelines for HBV related compensated liver cirrhosis in China. Therefore, the investigators aim to investigate clinical effects and cost-effectiveness of two early anti-viral therapy strategies on HBV related compensated liver cirrhosis through this prospective, open-label, multicenter and nonrandomized study.
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Beijing Friendship Hospital
Collaborators:
Beijing 302 Hospital
Beijing Ditan Hospital
Beijing Tiantan Hospital
Beijing YouAn Hospital
Peking Union Medical College Hospital
Peking University First Hospital
Peking University People's Hospital
Treatments:
Adefovir
Adefovir dipivoxil
Antiviral Agents
Entecavir
Lamivudine
Criteria
Inclusion Criteria:

- written informed consent

- aged 18-70 years

- clinical diagnosis of compensated liver cirrhosis

1. liver biopsy showing cirrhosis

2. endoscopy: esophageal varices , exclusion of noncirrhotic portal hypertension

3. if no biopsy or endoscopy ,should meet two of the four:

- Imaging(US, CT or MRI, et al) showing Surface nodularity: Echogenecity
(spleen pachydiameter > 4.0cm or> 5 costal region)

- PLT < 100×10 < 9 >/L,no other interpretation

- ALB < 35.0 g/L, or INR > 1.3, or CHE < 5.0KU/L

- Liver stiffness measurement value > 12.4 kpa

- HBeAg(+)with HBVDNA > 10 < 3 > IU/mL or HBeAg(-) wtih HBVDNA > 102 IU/mL

Exclusion Criteria:

- patient with decompensated liver cirrhosis:presence of ascites, variceal
hemorrhage,hepatic encephalopathy

- allergic to any ingredients of the drugs

- patient complicated with alcoholic liver disease, autoimmune liver disease, heretic
liver disease, drug induced liver disease,nonalcoholic liver disease or other chronic
liver disease.

- AFP > 100ng/ml or Cr > 1.5×ULN

- pregnant woman

- patient with severe disease or other organ failure

- patient with any tumors

- patient with sever mental disease.

- patients with any disease or condition which the investigator or treating physician
feels would interfere with the trial or the safety of the subject