Clinical Characteristics and Treatment of Chest Tightness Variant Asthma
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that
threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of
breath, chest tightness and cough, usually occurring at night or early morning. However,
there are still some patients with only persistent clinical manifestations of chest
tightness. Concerned about this group of patients, investigators presented a subgroup of
bronchial asthma, namely, chest tightness variant asthma (CTVA). This asthma subgroup usually
lacks asthma-specific clinical features such as wheezing, shortness of breath, wheezing, and
therefore often misdiagnosed for a long time. However, there is lack of definite treatment
strategy for CTVA. In order to further understand the clinical characteristics and treatment
of patients with CTVA, investigators conducted a national multicenter randomized control
trial(RCT) study that compares inhaled corticosteroid(ICS)/ long-acting beta2-agonist(LABA) +
Montelukast with ICS/LABA. Finally, investigators plan to clarify whether ICS/LABA plus
Montelukast is more appropriate treatment than only ICS/LABA in CTVA patients.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University