Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS)
Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
The main purpose of the study is to determine noninvasive markers of brain involvement in
Chagas disease. In a subgroup of patients with high intensity transient signals (HITS) on
transcranial Doppler monitorization, the investigators aim to determine the efficacy and
safety of aspirin in preventing microembolization in patients with no previous history of
stroke. Specific aims are listed bellow:
(1) to establish brain magnetic resonance imaging markers of stroke risk in patients with
Chagasic heart failure (HF); (2) to determine whether biomarkers can predict stroke risk in
patients with Chagasic HF; and (3) to evaluate the efficacy of antiplatelet treatment in
decreasing microembolization rate in patients with Chagasic HF.
Phase:
Phase 4
Details
Lead Sponsor:
Federal University of Bahia
Collaborators:
National Institute of Neurological Disorders and Stroke (NINDS) National Institutes of Health (NIH)