Clarithromycin Mechanisms in Hypersomnia Syndromes
Status:
Recruiting
Trial end date:
2024-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate a medication called clarithromycin for treating
sleepiness in two related conditions, narcolepsy without cataplexy and idiopathic
hypersomnia. Studies have shown that clarithromycin can reduce sleepiness, but researchers do
not know how clarithromycin does this. This study will look at brain activity (on magnetic
resonance imaging [MRI] and electroencephalogram [EEG] brainwaves), inflammation, bacteria
living in the gut, and cerebrospinal fluid, to better understand how clarithromycin can
reduce sleepiness. This study will recruit 92 participants who will be randomized to receive
clarithromycin or a placebo for 14 days.
Phase:
Phase 2
Details
Lead Sponsor:
Emory University
Collaborator:
National Institute of Neurological Disorders and Stroke (NINDS)