Civilian Post-Traumatic Stress Disorder Risperidone Clinical Trial

• Status: Completed
• Trial end date: 2006-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether the administration of risperidone is effective in the treatment of selective serotonin reuptake inhibitor (SSRI)-resistant post-traumatic stress disorder (PTSD) in civilians.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Emory University
• Collaborator: Janssen, LP
• Treatments: Risperidone; Sertraline

Criteria

Inclusion Criteria:

• Meets criteria for DSM-IV PTSD for a minimum of one month duration

• Clinician-Administered PTSD Scale (CAPS) score > or = to 50

• Able to read and complete questionnaires and interviews

• Negative urine drug screen

Exclusion Criteria:

• Pregnant or nursing

• Primary psychotic disorder; psychotic disorder; or cognitive disorder.

• Prominent suicidal or homicidal ideation

• Alcohol or substance dependence within 3 months of starting study

• Primary anxiety disorder or bipolar disorder

• Patients currently being treated with antipsychotic medication

• Patients in active psychotherapy aimed at PTSD

• Combat-related PTSD