Citalopram and Self Emotional Processing

• Status: Unknown status
• Trial end date: 2020-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is investigating the effect of an acute dose of citalopram on emotional processing about the self. Using a parallel-group double-blind design, participants will be randomised to receive either an acute dose of citalopram or placebo. Participants will then complete a number of widely used computer-based cognitive tasks measuring emotional processing biases towards the self.

This study has also been registered on OSF:

https://osf.io/nhjvs/?view_only=b39c49bddfd543b99b627dc992e49b45

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oxford
• Collaborator: University of Bath
• Treatments: Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• Male or Female

• Aged 18 -45 years

• Fluent in written and spoken English at a sufficient level to understand and complete the tasks

• Body Mass Index (BMI) 18-30

• Participant is willing and able to give informed consent for participation in the study

• Not currently taking any regular medications (expect the contraceptive pill)

Exclusion Criteria:

• Any past or current Axis 1 DSM-V psychiatric disorder

• Current use of psychoactive medication (except the contraceptive pill, the Depo-Provera injection or the progesterone implant)

• Current or past history of drug or alcohol dependency

• History of current significant neurological condition (e.g. epilepsy)

• Known hypersensitivity to the study drug

• Currently pregnant or breast feeding

• Previous participation in a study that uses the same or similar computer tasks as those used in the present study

• Previous participation in a study that involves the use of a medication within the last three months

• Significant medical condition

• Smokers consuming > 5 cigarettes per day

• Individuals consuming > 6 caffeinated drinks per day

• Lactose Intolerance (due to the study involving administration of a lactose placebo tablet)