Citalopram Versus Citalopram Plus Pindolol in Major Depressive Disorder

• Status: Completed
• Trial end date: 2005-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine whether the speed of the clinical antidepressant action of citalopram can be accelerated by administering double doses of pindolol (15 mg/day, tid) which presumably should lead to increased 5-HT1A autoreceptor occupancy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
• Treatments: Citalopram; Dexetimide; Pindolol

Criteria

Inclusion Criteria:

• Patients with a depressive episode

• HDRS score > 18

• Written informed consent

Exclusion Criteria:

• suicidal risk > 3

• severe organic illness

• other psychotropic drugs