Citalopram Titration in Early Non-responder Patients With Major Depressive Disorders
Status:
Completed
Trial end date:
2018-12-08
Target enrollment:
Participant gender:
Summary
Major depressive disorder is a common mental disorder and the leading cause of disability
worldwide. According to the Canadian Network for Mood and Anxiety Treatment, early
improvement following an antidepressant treatment is correlated with response and remission.
Escalation of an antidepressant dose after 2 weeks, as opposed to 4 to 8 weeks, is proposed
to favor early improvement. However, this has never been tested systematically in a
controlled study involving major depressive disorder patients that are non-responders to
their antidepressant treatment.